The cells of Mycobacterium tuberculosis detect, move, and sequester toxic copper via membrane copper pumps and protein chaperones.

“Copper is an essential micronutrient that is involved in protein-mediated electron transfer and enzyme activity, yet reduced copper in its +1 oxidation state is highly toxic to cells. As a result, cellular regulation of copper is highly controlled, involving cell-surface copper pumps and chaperones that move copper around the cell, delivering it to specific target proteins and concurrently sequestering it to protect the cell from toxicity.” (Wilmot 2007:15)

Last Updated October 24, 2016