The cells of Mycobacterium tuberculosis detect, move, and sequester toxic copper via membrane copper pumps and protein chaperones.

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“Copper is an essential micronutrient that is involved in protein-mediated electron transfer and enzyme activity, yet reduced copper in its +1 oxidation state is highly toxic to cells. As a result, cellular regulation of copper is highly controlled, involving cell-surface copper pumps and protein chaperones that move copper around the cell, delivering it to specific target proteins and concurrently sequestering it to protect the cell from toxicity.” (Wilmot 2007:15)

Journal article
Fighting toxic copper in a bacterial pathogenNature Chemical BiologyDecember 15, 2006
Carrie M Wilmot

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