In order for a cell to divide properly, certain enzymes must be activated. When these enzymes are present, the cell division proceeds normally, as in the path that drifts to the left in the picture above. When these enzymes become blocked, or inhibited, the cell division is paused and thus the cells cannot fully separate, as seen above in the path that drifts to the right.
Artist: Emily Harrington. Copyright: All rights reserved. See gallery for details.
"Growth of MRSA was inhibited by 5%, 10% and 20% (w/v) manuka honey… Methylglyoxal (MGO) was identified as the dominant active antibacterial component of manuka honey (MH)." (Jenkins et al. 2011: 2536)
"MH would have to be diluted by a factor of ≥20 to reach subinhibitory levels... the four major constituent sugars present in honey were not entirely responsible for the inhibition of MRSA." (Jenkins et al. 2011: 2539)
"The accumulation of cells containing whole or incomplete septa has shown that MH interrupted the cell cycle of S. aureus...The accumulation of cells with significantly larger diameters following incubation with inhibitory concentrations of MH indicates that cells had reached a late stage in the cell cycle, where cell division rather than metabolic activity associated with increased cell volume was impaired." (Jenkins et al. 2011: 2540)
"..Murein hydrolases were implicated in the failure of S. aureus to divide." (Jenkins et al. 2011: 2541)