Blue mussels (Mytilus edulis) – bivalves that attach to rocks in wave-battered intertidal seashores – produce adhesives comparable in strength to human-made glues but without carcinogens such as formaldehyde and which can cure under water.

A key feature of the blue mussel’s unique adhesive chemistry is the presence of the amino acid 3,4-dihydroxyphenylalanine, with its reactive catechol functional group (two hydroxyl groups sticking out from a benzene ring) that forms strong bonds with catechols on adjacent molecules and with metal atoms present in the surface of most natural solid substrates. Another key feature is the ability of catechol chains to overcome a solid surface’s otherwise strong preference for water molecules (which is why conventional adhesives fail on wet surfaces).

New mussel-inspired adhesives, which have wide-ranging applications from surgical to wood composites, currently use soy as an inexpensive, accessible feedstock, and work by blocking certain amino acids in soy proteins that are not present in mussel proteins, such as glutamic acid, so that the resulting compound bears a closer resemblance to that of mussel proteins.


“Pounding waves are no match for the mighty mussel, that produces strong, flexible threads that cling to rocks…mussels secrete a unique amino acid called dihydroxyphenylalanine…Researchers have developed a new group of adhesives for wood products inspired by the ability of mussels to cling to rocks using thread-like tentacles. These threads are proteins that retain powerful adhesive properties even in water.” (ScienceDaily 2005)

Web page
Wood Glue Inspired by Mussels: Chemist's Glue Borrows Unique Amino Acid from Mollusk

Journal article
Mussel-Inspired Surface Chemistry for Multifunctional CoatingsScienceOctober 20, 2016
H. Lee, S. M. Dellatore, W. M. Miller, P. B. Messersmith

Mediterranean MusselMytilus edulisSpecies