Mucins Trap Pathogens

Biological Strategy

Animals

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Protect From Microbes

In living systems, microbes play important roles, such as breaking down organic matter and maintaining personal and system health. But they also pose threats. Bacteria can be pathogens that cause diseases. Some bacteria create colonies called biofilms that can coat surfaces, reducing their effectiveness–for example, inhibiting a leaf’s ability to photosynthesize. Living systems must have strategies for protecting from microbes that cause disease or become so numerous that they create an imbalance in the system. At the same time, living systems must continue living in harmony with other microbes. Some living systems kill microbes. Others repel without killing to reduce the chances that microbes will adapt to the lethal strategy and become resistant to it. For example, some pea seedlings exude a chemical that inhibits biofilm buildup.

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Animals

Kingdom Animalia (“having breath or soul”): Mammals, reptiles, sponges, corals, insects, birds

This kingdom captures a staggering variety of life—from the smallest coral polyp to the largest elephant. Although animal body shapes and life histories vary, there are a few defining characteristics. Animals are heterotrophs, meaning they gain energy from eating other organisms, and have developed from single-celled ancestors to highly diversified and coordinated multicellular forms. Unlike plant and fungi cells that have rigid cell walls, animal cells are bound by more flexible combinations of proteins. Most animals have cells organized into tissues and are able to move within their environment.

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Mucins of animals stop invading pathogens by being coated with sugar chains that trap the invaders.

“Researchers at the University of Massachusetts and Yale University are looking for ways to trap viruses. In order to reproduce, viruses need to invade a host cell and replicate using the cell’s own DNA-replication system. The researchers figured that if they could lure viruses to decoy cells, they could reduce the viral load enough for someone with HIV or other disease for that person’s own immune system to successfully fight off the attack. Mucins are proteins found in most body fluids. They are coated with sugar chains that trap invading pathogens. Red blood cells also appear to act as pathogen traps. One approach is to coat nanoparticles with viral receptors. Another approach is to add decoy attachment sites to red blood cells. One advantage of using viral traps is it would be hard for viruses to evolve resistance to them.” (Courtesy of the Biomimicry Guild)

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