Osteoclasts/osteoblasts of bones maintain skeletal homeostasis by resorbing bone/forming newly synthesized matrix.

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“Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone…Bone remodeling is a temporally and spatially regulated process that results in the coordinated resorption and formation of skeletal tissue (1). Bone remodeling is carried out in basic multicellular units in which osteoclasts resorb bone and osteoblasts form newly synthesized matrix in a coordinated process that takes about 4 months…The number and function of osteoclasts and osteoblasts are regulated by extracellular and intracellular signals acting in a coordinated fashion to maintain skeletal homeostasis.” (Canalis 2008:1)

Journal article
Notch Signaling in OsteoblastsScience SignalingJune 24, 2008
E. Canalis

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