Skin Protects From Fungal Pathogens

overhead view of variety of orange pumpkins

Biological Strategy

Winter squash

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Image: Andrea Lambrecht / Unsplash / Free non-commercial use

Protect From Fungi

Fungi–which include molds and mushrooms, amongst others–play important roles in every ecosystem, but can also create diseases in plants and animals. Fungi can rapidly reproduce, so living systems must fend them off early to avoid their spread and potential, physical harm. Living systems use both physical and chemical strategies to protect from fungi, and must ensure that these strategies don’t harm the threatened living system itself. For example, a pumpkin’s skin has antifungal proteins to prevent fungal growth without harming the pumpkin itself.

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Biological Control of Populations, Pests, Diseases

An ecosystem must prevent overpopulation of any given species within it, as well as the spread of pests and diseases, to allow organisms to survive without threatening extermination of other organisms or ecosystems. To control pests and diseases, living systems use such strategies as developing antibodies and killing or repelling pests or disease-causing organisms. Ecosystems have checks and balances to maintain populations, pests, and diseases. For example, in a lake, a balance of predators, prey, and nutrients is crucial for proper functioning of the ecosystem. Predatory fish keep down the numbers of smaller prey fish, which in turn keep populations of algae-eating zooplankton in check. When the levels of any of these organisms change, the change can disrupt the health of the entire ecosystem.

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Flowering Plants

Clade Angiosperms (“receptacle seed”): Dandelions, oaks, grasses, cacti, apples

With 416 families containing some 300,000 known species, angiosperms are the most diverse group of plants, and they can be found around the globe in a wide variety of habitats. They are characterized by seeds that grow enclosed in ovaries, which are enclosed in flowers. The floral organs then develop into fruits of myriad kinds and dimensions, from simple seed casings on maples to elaborate fleshy growths like papayas. The oldest flower known from fossils, Montsechia vidalii, appeared during the Jurassic Period 130 million years ago. They are the primary food source for herbivorous animals, which in turn makes them the indirect food source for carnivores as well.

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Skin of pumpkins helps protect them from fungal pathogens using unique antifungal proteins.

The skin of that pumpkin you carve into a Jack-o’-Lantern to scare away ghosts and goblins on Halloween contains a substance that could put a scare into microbes that cause millions of cases of yeast infections in adults and infants each year. Scientists Kyung-Soo Hahm and Yoonkyung Park note that some disease-causing microbes are becoming resistant to existing antibiotics. As a result, scientists worldwide are searching for new antibiotics. Past studies hinted that pumpkin, long used as folk medicine in some countries, might have antibiotic effects.

The scientists extracted s from pumpkin rinds to see if the proteins inhibit the growth of microbes, including Candida albicans (C. albicans). That fungus causes vaginal yeast infections, diaper rash in infants, and other health problems. One protein had powerful effects in inhibiting the growth of C. albicans, in cell culture experiments, with no obvious toxic effects. The pumpkin protein could be developed into a natural medicine for fighting yeast infections in humans, the report suggests. The protein also blocked the growth of several fungi that attack important plant crops and could be useful as an agricultural fungicide.

Adapted from “Pumpkin Skin May Scare Away Germs” (EurekAlert! 2009)

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Last Updated October 23, 2019

References

Pumpkin skin may scare away germs

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Reference

Journal article

Antifungal Mechanism of a Novel Antifungal Protein from Pumpkin Rinds against Various Fungal Pathogens

J. Agric. Food Chem. | 22/09/2009 | Seong-Cheol Park, Jin-Young Kim, Jong-Kook Lee, Indeok Hwang, Hyeonsook Cheong, Jae-Woon Nah, Kyung-Soo Hahm, Yoonkyung Park

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